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The Gallbladder - Function, Anatomy, and Disease States The gallbladder is a small pear-shaped organ located in the right upper quadrant of the abdomen. Its function is to store, concentrate, and secrete bile in response to eating (particularly a fatty meal). The likelihood of gallbladder disease may be increased with a family history, pregnancy, race (Native Americans), and perhaps with equated serum cholesterol. Though gallbladder disease is most common in the middle age group, it also can be seen in children and in the aged. Fall General Surgery has removed the gallbladder in patients as young